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doi: 10.1371/journal.pone.0057610 122 HanBMengXChenHChenLLiuXWangHet al

Pharmaceuticals 17(8):975 Rosiak N, Tykarska E, Cielecka-Piontek J (2024) Enhanced antioxidant and neuroprotective properties of pterostilbene (resveratrol derivative) in amorphous solid dispersions

A Mendelian randomization analysis study (209) detected that lowering LDL-C and PCSK9 protein levels by PCSK9 variants was relevant to an increase in CB, demonstrating that direct bilirubin is increased with the use of newer lipid-lowering therapies like the preprotein convertase chytokeratase/kexin type 9 (PCSK9), monoclonal antibody inhibitors: alirocumab and evolocumab, and hepatic PCSK9 siRNA inhibitor inclisiran

The plasmid system is relatively stable but has low cutting and editing efficiency, and continuous expression of Cas9 may increase off-target effects